REBEL Cast Ep116 - May 18, 2023 - By Salim Rezaie
Author Conclusion: “Among patients with sepsis-induced hypotension, the restrictive fluid strategy that was used in this trial did not result in significantly lower (or higher) mortality before discharge home by day 90 than the liberal fluid strategy.”
Clinical Take Home Point: In a group of patients with septic shock (sepsis-induced hypotension), receiving initial treatment with 1 to 3 liters of IV fluids, a restrictive fluid strategy (with early vasopressor use) did not result in a significantly lower (or higher) mortality before discharge home by day 90 compared to a liberal fluid strategy. Basically, in a heterogenous disease process like sepsis, use your clinical judgement to determine how much fluid any particular patient needs.