The CLOVERS 🍀 Trial

TAMING THE SRU

The CLOVERS 🍀 Trial

TAMING THE SRU - May 05, 2023 - By Lausen Gillespie

Ref: National Heart, Lung, and Blood Institute Prevention and Early Treatment of Acute Lung Injury Clinical Trials Network, Shapiro NI, Douglas IS, et al. Early Restrictive or Liberal Fluid Management for Sepsis-Induced Hypotension. N Engl J Med. 2023;388(6):499-510. doi:10.1056/NEJMoa2212663

...Overall, both restrictive and liberal fluid strategies in the initial resuscitation of patients with septic shock, when applied to the appropriate patient populations, are viable strategies for care based on the provided endpoints and subgroup and post-hoc analyses. This study raised some interesting potential questions and hypotheses for future studies based on the subgroup analyses, and demonstrated excellent safety for the administration of peripheral vasopressors.